Hepatocyte nuclear factor 3 (winged helix domain) activates trefoil factor gene TFF1 through a binding motif adjacent to the TATAA box.

@article{Beck1999HepatocyteNF,
  title={Hepatocyte nuclear factor 3 (winged helix domain) activates trefoil factor gene TFF1 through a binding motif adjacent to the TATAA box.},
  author={Samuel Beck and Pascal Sommer and E dos Santos Silva and Nikolaus Blin and Peter G{\"o}tt},
  journal={DNA and cell biology},
  year={1999},
  volume={18 2},
  pages={157-64}
}
The winged helix transcription factors HNF-3/FKH (forkhead homologs) activate endodermal-derived and acute-phase gene expression and control gut development in Drosophila. Trefoil factor family (TFFs) peptides are vertebrate products secreted by mucin-producing epithelial cells of the gastrointestinal tract involved in restitution and repair of the mucosa. They are positively regulated in ulcerative and neoplastic conditions. We describe a consensus sequence in human and rodent TFF promoters… CONTINUE READING
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