Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.

@article{Emens1992HepatocyteNF,
  title={Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene.},
  author={Leisha Emens and D W Landers and Larry G. Moss},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1992},
  volume={89 16},
  pages={7300-4}
}
Systematic mutational analysis previously identified two primary regulatory elements within a minienhancer (-247 to -198) of the rat insulin I promoter that are critical for transcriptional activity. The Far box (-241 to -232) and the FLAT element (-222 to -208) synergistically upregulate transcription and, together, are sufficient to confer tissue-specific and glucose-responsive transcriptional activity on a heterologous promoter. Detailed analysis of the FLAT element further revealed that, in… CONTINUE READING

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