Hepatocyte nuclear factor‐1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF‐1β in human pancreatic development

@article{Edghill2006HepatocyteNF,
  title={Hepatocyte nuclear factor‐1 beta mutations cause neonatal diabetes and intrauterine growth retardation: support for a critical role of HNF‐1$\beta$ in human pancreatic development},
  author={E. Edghill and C. Bingham and A. S. Slingerland and J. Minton and C. Noordam and S. Ellard and A. Hattersley},
  journal={Diabetic Medicine},
  year={2006},
  volume={23}
}
Aim  The transcription factor hepatocyte nuclear factor‐1beta (HNF‐1β) is expressed in rodent pancreatic progenitor cells, where it is an important member of the genetic hierarchy that regulates the generation of pancreatic endocrine and exocrine cells. The recent description of an HNF‐1β mutation in a patient with neonatal diabetes suggests that HNF‐1β may also play a key role in human pancreatic B‐cell development. We aimed to investigate the role of HNF‐1β mutations in neonatal diabetes and… Expand
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