Hepatocyte heterogeneity in response to icosanoids. The perivenous scavenger cell hypothesis.

@article{Hussinger1988HepatocyteHI,
  title={Hepatocyte heterogeneity in response to icosanoids. The perivenous scavenger cell hypothesis.},
  author={Dieter H{\"a}ussinger and Thomas Stehle},
  journal={European journal of biochemistry},
  year={1988},
  volume={175 2},
  pages={395-403}
}
1. The metabolic and hemodynamic effects of prostaglandin F2 alpha, leukotriene C4 and the thromboxane A2 analogue U-46619 were studied during physiologically antegrade (portal to hepatic vein) and retrograde (hepatic to portal vein) perfusion and in a system of two rat livers perfused in sequence. 2. The stimulatory effects of prostaglandin F2 alpha (3 microM) on hepatic glucose release, perfusion pressure and net Ca2+ release were diminished by 77%, 95% and 64%, respectively, during… CONTINUE READING