Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction.

@article{Yang2003HepatocyteGF,
  title={Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction.},
  author={Junwei Yang and Chunsun Dai and Youhua Liu},
  journal={The American journal of pathology},
  year={2003},
  volume={163 2},
  pages={621-32}
}
Interstitial myofibroblasts are alpha-smooth muscle actin-positive cells that play a crucial role in the accumulation of excess extracellular matrix during renal interstitial fibrogenesis. Despite their importance in the pathogenesis of renal fibrosis, relatively little is known about the regulators and the mechanism controlling the activation of renal interstitial myofibroblasts in disease conditions. Here, we show that hepatocyte growth factor (HGF) acts as a potent inhibitor of the… CONTINUE READING

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Here , we show that hepatocyte growth factor ( HGF ) acts as a potent inhibitor of the transforming growth factor ( TGF)-beta1-mediated myofibroblastic activation from normal rat renal interstitial fibroblasts ( NRK-49F ) .
Here , we show that hepatocyte growth factor ( HGF ) acts as a potent inhibitor of the transforming growth factor ( TGF)-beta1-mediated myofibroblastic activation from normal rat renal interstitial fibroblasts ( NRK-49F ) .
To decipher the mechanism underlying HGF antagonizing TGF - beta1 's action , we examined the effects of HGF on TGF - beta1-mediated Smad signaling .
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