Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro.

@article{Shiratori1995HepatocyteGF,
  title={Hepatocyte growth factor stimulates DNA synthesis in alveolar epithelial type II cells in vitro.},
  author={Miwa Shiratori and George Michalopoulos and Hisashi Shinozuka and Gurmukh Singh and Hitoshi Ogasawara and Sikandar L. Katyal},
  journal={American journal of respiratory cell and molecular biology},
  year={1995},
  volume={12 2},
  pages={171-80}
}
Hepatocyte growth factor (HGF) and its receptor, the product of c-MET proto-oncogene, are highly expressed in both fetal and adult lung, though their physiologic functions in the lung are largely unknown. In the present study, we examined whether alveolar type II cells in the lung are the target of HGF and whether HGF has any effects on growth of these cells. The alveolar epithelial type II cells were isolated from the lungs of adult male Sprague-Dawley rats by elastase digestion, and the cells… CONTINUE READING
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