Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury.

@article{Jeong2012HepatocyteGF,
  title={Hepatocyte growth factor reduces astrocytic scar formation and promotes axonal growth beyond glial scars after spinal cord injury.},
  author={Soo Ryeong Jeong and Min Kwon and Hwan Goo Lee and Eun Hye Joe and Jae Ho Lee and Sung Soo Kim and Haeyoung Suh-Kim and Byung Gook Kim},
  journal={Experimental neurology},
  year={2012},
  volume={233 1},
  pages={312-22}
}
The formation of glial scars impedes growth of regenerating axons after CNS injuries such as spinal cord injury (SCI). Hepatocyte growth factor (HGF), originally identified as a mitogen for hepatocytes, exerts pleiotropic functions in the nervous system. HGF has been implicated in peripheral wound healing via regulation of the transforming growth factor beta (TGFβ), which is also a potent inducer of glial scar formation in CNS. In the present study, we found that HGF completely blocked… CONTINUE READING