Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine

@article{Horiguchi2002HepatocyteGF,
  title={Hepatocyte growth factor promotes hepatocarcinogenesis through c-Met autocrine activation and enhanced angiogenesis in transgenic mice treated with diethylnitrosamine},
  author={Norio Horiguchi and Hisashi Takayama and Mitsuo Toyoda and Toshiyuki Otsuka and Toshio Fukusato and Glenn Merlino and Hitoshi Takagi and Masatomo Mori},
  journal={Oncogene},
  year={2002},
  volume={21},
  pages={1791-1799}
}
Hepatocyte growth factor (HGF) is a mitogen for hepatocytes, but it is not clear whether HGF stimulates or inhibits hepatocarcinogenesis. We previously reported that HGF transgenic mice under the metallothionein gene promoter developed benign and malignant liver tumors spontaneously after 17 months of age. To elucidate the role of HGF in hepatocarcinogenesis, diethylnitrosamine (DEN) was administered to HGF transgenic mice. HGF overexpression accelerated DEN-induced hepatocarcinogenesis, often… CONTINUE READING

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