Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.

@article{Tojima2012HepatocyteGF,
  title={Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis.},
  author={Hiroki Tojima and Satoru Kakizaki and Takashi Kosone and Norio Horiguchi and Yuichi Yamazaki and Ken Sato and Hitoshi Takagi and Masatomo Mori},
  journal={Hepatology international},
  year={2012},
  volume={6 3},
  pages={620-30}
}
BACKGROUND Hepatocyte growth factor (HGF) is a potent growth factor involved in liver regeneration that has various effects on epithelial and nonepithelial cells. Although it has been demonstrated that HGF can reduce liver inflammation or fibrosis caused by pharmaceutical or chemical insult, no examination of its effect on liver injury in nonalcoholic steatohepatitis (NASH) has been reported. METHODS To examine the effect of HGF on liver injury in NASH, we generated a murine steatohepatitis… CONTINUE READING