Hepatocyte growth factor mRNA in human liver cirrhosis as evidenced by in situ hybridization.

BACKGROUND Hepatocyte growth factor (HGF) is a strong mitogen of hepatocytes, and HGF-producing cells have been reported to be Ito cells or endothelial cells in the sinusoid of the liver. No reports have been published about the localization of HGF mRNA in human liver cirrhosis. METHODS In situ hybridization (ISH) for HGF mRNA was performed in 5 normal… CONTINUE READING