Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells.

@article{Benkhoucha2014HepatocyteGF,
  title={Hepatocyte growth factor limits autoimmune neuroinflammation via glucocorticoid-induced leucine zipper expression in dendritic cells.},
  author={Mahdia Benkhoucha and Nicolas Molnarfi and Isabelle Dunand-Sauthier and Doron Merkler and Gregory Schneiter and Stefano Bruscoli and Carlo Riccardi and Yasuhiko Tabata and Hiroshi Funakoshi and Toshikazu Nakamura and Walter Reith and Marie-Laure Santiago-Raber and Patrice H. Lalive},
  journal={Journal of immunology},
  year={2014},
  volume={193 6},
  pages={
          2743-52
        }
}
Autoimmune neuroinflammation, including multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis (EAE), a prototype for T cell-mediated autoimmunity, is believed to result from immune tolerance dysfunction leading to demyelination and substantial neurodegeneration. We previously showed that CNS-restricted expression of hepatocyte growth factor (HGF), a potent neuroprotective factor, reduced CNS inflammation and clinical deficits associated with EAE. In this study, we… CONTINUE READING

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Glucocorticoid-Induced Leucine Zipper: Fine-Tuning of Dendritic Cells Function

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