Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer

  title={Hepatocyte growth factor inhibition: a novel therapeutic approach in pancreatic cancer},
  author={Srinivasa P. Pothula and Zhihong Xu and David Goldstein and Andrew V. Biankin and Romano Cesare Pirola and Jeremy Somers Wilson and Minoti Vivek Apte},
  booktitle={British Journal of Cancer},
Background:Pancreatic stellate cells (PSCs, which produce the stroma of pancreatic cancer (PC)) interact with cancer cells to facilitate PC growth. A candidate growth factor pathway that may mediate this interaction is the HGF–c-MET pathway.Methods:Effects of HGF inhibition (using a neutralising antibody AMG102) alone or in combination with gemcitabine were assessed (i) in vivo using an orthotopic model of PC, and (ii) in vitro using cultured PC cells (AsPC-1) and human PSCs.Results:We have… CONTINUE READING
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