Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade.

@article{Reboul2001HepatocyteGF,
  title={Hepatocyte growth factor induction of collagenase 3 production in human osteoarthritic cartilage: involvement of the stress-activated protein kinase/c-Jun N-terminal kinase pathway and a sensitive p38 mitogen-activated protein kinase inhibitor cascade.},
  author={Pascal Reboul and J. J. Pelletier and Ginette Tardif and Mohamed Benderdour and Pierre Ranger and Donald P Bottaro and Johanne Martel-Pelletier},
  journal={Arthritis and rheumatism},
  year={2001},
  volume={44 1},
  pages={73-84}
}
OBJECTIVE Osteoarthritis (OA) involves both a decreased reparative process and an increased degradative phenomenon. Several cytokines and growth factors are known to facilitate the repair of articular cartilage defects. The hepatocyte growth factor (HGF) present in OA cartilage is suggested to be involved in the cartilage repair process as well as in matrix remodeling and chondrocyte migration, leading to partial reconstruction of articular cartilage. Since cell migration is often correlated… CONTINUE READING