Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin.

@article{OrianRousseau2007HepatocyteGF,
  title={Hepatocyte growth factor-induced Ras activation requires ERM proteins linked to both CD44v6 and F-actin.},
  author={V{\'e}ronique Orian-Rousseau and Helen C. Morrison and Alexandra Matzke and Thor Kastilan and Giuseppina Pace and Peter A. Herrlich and Helmut Ponta},
  journal={Molecular biology of the cell},
  year={2007},
  volume={18 1},
  pages={
          76-83
        }
}
In several types of cells, the activation of the receptor tyrosine kinase c-Met by its ligand hepatocyte growth factor (HGF) requires the coreceptor CD44v6. The CD44 extracellular domain is necessary for c-Met autophosphorylation, whereas the intracellular domain is required for signal transduction. We have already shown that the CD44 cytoplasmic tail recruits ezrin, radixin and moesin (ERM) proteins to the complex of CD44v6, c-Met, and HGF. We have now defined the function of the ERM proteins… CONTINUE READING
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