Hepatocyte growth factor improved learning and memory dysfunction of microsphere-embolized rats.

@article{Date2004HepatocyteGF,
  title={Hepatocyte growth factor improved learning and memory dysfunction of microsphere-embolized rats.},
  author={Ichiro Date and Norio Takagi and Keiko Takagi and Tomoyuki Kago and Kunio Matsumoto and Toshikazu Nakamura and Satoshi Takeo},
  journal={Journal of neuroscience research},
  year={2004},
  volume={78 3},
  pages={442-53}
}
Hepatocyte growth factor (HGF), an organotropic factor for regeneration and protection in various organs, has the ability to attenuate cerebral ischemia-induced cell death. The effect of HGF on learning and memory function after cerebral ischemia, however, remains unknown. We have demonstrated that administration of human recombinant HGF (hrHGF) into the ventricle reduced prolongation of the escape latency in acquisition and retention tests of the water maze task on Days 12-28 after microsphere… CONTINUE READING