Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.

@article{Chanda2009HepatocyteGF,
  title={Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes.},
  author={Dipanjan Chanda and Tiangang Li and Kwang Hoon Song and Yong-Hoon Kim and Jeonggu Sim and Chul Ho Lee and John Y. L. Chiang and Hueng-Sik Choi},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 42},
  pages={28510-21}
}
Hepatic gluconeogenesis is tightly balanced by opposing stimulatory (glucagon) and inhibitory (insulin) signaling pathways. Hepatocyte growth factor (HGF) is a pleiotropic growth factor that mediates diverse biological processes. In this study, we investigated the effect of HGF and its family member, macrophage-stimulating factor (MSP), on hepatic gluconeogenesis in primary hepatocytes. HGF and MSP significantly repressed expression of the key hepatic gluconeogenic enzyme genes… CONTINUE READING

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HGF Family Inhibits Hepatic Gluconeogenesis

W. Cao, Q. F. Collins, +7 authors S. Collins
J. Biol. Chem • 2005
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