Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice.

@article{Inoue2003HepatocyteGF,
  title={Hepatocyte growth factor counteracts transforming growth factor-beta1, through attenuation of connective tissue growth factor induction, and prevents renal fibrogenesis in 5/6 nephrectomized mice.},
  author={Tsutomu Inoue and Hirokazu Okada and Tatsuya Kobayashi and Yusuke Watanabe and Yoshihiko Kanno and Jeffrey B. Kopp and Takashi Nishida and Masaharu Takigawa and Munehisa Ueno and Toshikazu Nakamura and Hiromichi Suzuki},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  year={2003},
  volume={17 2},
  pages={268-70}
}
We investigated the mechanism of the anti-fibrotic effects of hepatocyte growth factor (HGF) in the kidney, with respect to its effect on connective tissue growth factor (CTGF), a down-stream, profibrotic mediator of transforming growth factor-beta1 (TGF-beta1). In wild-type (WT) mice with 5/6 nephrectomy (Nx), HGF and TGF-beta1 mRNAs increased transiently in the remnant kidney by week 1 after the Nx, returned to baseline levels, and increased again at weeks 4 to 12. In contrast, CTGF and… CONTINUE READING

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