Hepatocyte growth factor as a potential index of complication in diabetes mellitus

@article{Nakamura1998HepatocyteGF,
  title={Hepatocyte growth factor as a potential index of complication in diabetes mellitus},
  author={Shigefumi Nakamura and Ryuichi Morishita and Atsushi Moriguchi and Yoshikage Yo and Yoshio Nakamura and Shin-ichiro Hayashi and Keiko Matsumoto and Kunio Matsumoto and Toshikazu Nakamura and Jitsuo Higaki and Toshio Ogihara},
  journal={Journal of Hypertension},
  year={1998},
  volume={16},
  pages={2019–2026}
}
Objective Diabetes mellitus (DM), characterized by the premature development of microvascular and macrovascular disease, shows a loss of vasodilatory properties of resistance vessels. However, the mechanisms of endothelial dysfunction in diabetes have not yet been clarified. Hepatocyte growth factor (HGF) in vascular cells was down-regulated by high glucose levels, potentially accelerating the endothelial dysfunction in DM. In this study, the serum HGF level was measured to investigate further… Expand
Hepatocyte growth factor, a biomarker of macroangiopathy in diabetes mellitus.
TLDR
The review indicates what is presently known regarding serum HGF might be a new and meaningful biomarker of macroangiopathy in DM subjects and a relationship between the elevated HGF concentrations and advancement of CA involvements is indicated. Expand
Hepatocyte growth factor predicts survival and relates to inflammation and intima media thickness in end-stage renal disease.
TLDR
The hypothesis that in patients with chronic renal failure, increased serum HGF level is linked to an inflammatory state is supported and this cytokine might be a marker of a process that has a major impact in the high mortality and morbidity of the dialysis population. Expand
Hepatocyte growth factor (HGF) as a potential index of severity of hypertension.
TLDR
It is suggested that HGF may be considered as a new index of the severity of hypertension, and might contribute to the protection and/or repair of vascular endothelial cells injured by high blood pressure. Expand
Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats
TLDR
The present data demonstrated the improvement of endothelial dysfunction by Ang II blockade in SHR-SM, accompanied by an increase in vascular HGF and c-met. Expand
Supplemental Tables Hepatocyte Growth Factor is Positively Associated with Risk of Stroke : The Multi-Ethnic Study of Atherosclerosis ( MESA )
The protein hepatocyte growth factor (HGF) and its receptor c-Met are produced in response to tissue injury and are functional in tissue repair mechanisms. Their favorable effects in the heart andExpand
Impaired endothelial dysfunction in diabetes mellitus rats was restored by oral administration of prostaglandin I2 analogue.
TLDR
Treatment with a PGI(2) analogue restored endothelial dysfunction in DM rats, accompanied by the induction of vascular HGF and c-met expression, and an increase in HGF protein was also confirmed by immunohistochemical analysis. Expand
Significance of serum circulating hepatocyte growth factor in the development of carotid atherosclerosis.
TLDR
It is suggested that increased serum HGF concentrations were associated with carotid atherosclerosis, independent of known risk factors for Atherosclerosis. Expand
Hepatocyte growth factor as cardiovascular hormone: role of HGF in the pathogenesis of cardiovascular disease.
TLDR
The results suggest that HGF secretion might be elevated in response to high blood pressure as a counter-system against endothelial dysfunction, and may be considered as an index of severity of hypertension. Expand
Hepatocyte growth factor and 24-hour ambulatory blood pressure monitoring.
TLDR
The results indicated that there is a relationship between blood pressure measured by ABPM and serum HGF concentration, and that this relationship might be an index of damage to blood vessels in patients with hypertension. Expand
Serum hepatocyte growth factor is associated with viral hepatitis, cardiovascular disease, erythropoietin treatment, and type of heparin in haemodialysis patients.
  • J. Borawski, M. Myśliwiec
  • Medicine
  • Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
  • 2002
TLDR
Serum HGF levels in HD patients are determined by inflammatory conditions such as viral hepatitis and CVD, increase in response to rHuEpo treatment, and may be influenced by type and dose of heparin used during HD procedures. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 49 REFERENCES
A novel vascular modulator, hepatocyte growth factor (HGF), as a potential index of the severity of hypertension.
TLDR
It is demonstrated that serum concentration of HGF is significantly elevated dependent on the severity of hypertension, suggesting that HGF may be a new index of the severity in hypertensive patients. Expand
Role of angiotensin II in the regulation of a novel vascular modulator, hepatocyte growth factor (HGF), in experimental hypertensive rats.
TLDR
Increased circulating HGF and decreased vascular, cardiac, and renal HGF in SHR as compared with WKY at the maintenance stage of hypertension is demonstrated, suggesting that decreased local HGF production may have an important role in the cardiovascular remodeling of target organs in hypertension. Expand
Potential Role of an Endothelium-Specific Growth Factor, Hepatocyte Growth Factor, on Endothelial Damage in Diabetes
TLDR
Overall, decrease in a local endothelial stimulant, HGF, by high D-glucose may be a trigger of endothelial injury in diabetes, potentially resulting in the progression of atherosclerosis. Expand
Role of hepatocyte growth factor in endothelial regulation: prevention of high D-glucose-induced endothelial cell death by prostaglandins and phosphodiesterase type 3 inhibitor
TLDR
It is demonstrated that treatment with PGE, PGI2 analogue or cilostazol prevented aortic EC death induced by high d-glucose, probably through the activation of local HGF production. Expand
Hypertension, the endothelial cell, and the vascular complications of diabetes mellitus.
TLDR
An overall approach to the understanding and treatment of diabetes mellitus and its complications will be to elucidate the mechanisms of vascular disease and endothelial cell dysfunction that occur in the setting of hypertension and diabetes. Expand
A vascular modulator, hepatocyte growth factor, is associated with systolic pressure.
TLDR
HGF is an endothelium-specific growth factor whose serum concentration is significantly associated with systolic pressure, and this results suggest that HGF secretion might be elevated in response to high blood pressure as a counterregulatory system against endothelial dysfunction. Expand
Expression of transforming growth factor beta is elevated in human and experimental diabetic nephropathy.
TLDR
It is reported that in glomeruli of rats made diabetic there is a slow, progressive increase in the expression of transforming growth factor beta (TGF- beta) mRNA and TGF-beta protein, which implicate TGF -beta in the pathogenesis of diabetic nephropathy. Expand
Expression of transforming growth factor-β1 during diabetic renal hypertrophy
TLDR
Total RNA was extracted from renal cortex and isolated glomeruli of streptozotocin-induced diabetic rats 24 hours, 48 hours, 96 hours, one and two weeks after the onset of hyperglycemia. Expand
Systemic hypertension and the renin-angiotensin system in diabetic vascular complications.
TLDR
Investigation of mechanisms will be important in determining the therapeutic role of inhibition of the RAS in diabetes mellitus, as well as potential activity of tissue RASs, increased sensitivity to angiotensin II in diabetes, or an effect of ACE inhibition on other systems in addition to the R AS. Expand
Expression of local hepatocyte growth factor system in vascular tissues.
TLDR
It is demonstrated that HGF is expressed and secreted from endothelial cells and VSMC of both rat and human in vitro as well as in vivo. Expand
...
1
2
3
4
5
...