Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2): Emerging key players in epithelial integrity and cancer.

@article{Kataoka2018HepatocyteGF,
  title={Hepatocyte growth factor activator inhibitors (HAI-1 and HAI-2): Emerging key players in epithelial integrity and cancer.},
  author={Hiroaki Kataoka and Makiko Kawaguchi and Tsuyoshi Fukushima and Takeshi Shimomura},
  journal={Pathology international},
  year={2018},
  volume={68 3},
  pages={
          145-158
        }
}
The growth, survival, and metabolic activities of multicellular organisms at the cellular level are regulated by intracellular signaling, systemic homeostasis and the pericellular microenvironment. Pericellular proteolysis has a crucial role in processing bioactive molecules in the microenvironment and thereby has profound effects on cellular functions. Hepatocyte growth factor activator inhibitor type 1 (HAI-1) and HAI-2 are type I transmembrane serine protease inhibitors expressed by most… CONTINUE READING

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