Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases.

@article{Cheng2009HepatocyteGF,
  title={Hepatocyte growth factor activator inhibitor type 1 regulates epithelial to mesenchymal transition through membrane-bound serine proteinases.},
  author={Haixia Cheng and Tsuyoshi Fukushima and Nobuyasu Takahashi and Hiroyuki Tanaka and Hiroaki Kataoka},
  journal={Cancer research},
  year={2009},
  volume={69 5},
  pages={1828-35}
}
Hepatocyte growth factor activator inhibitor-1 (HAI-1), encoded by the serine protease inhibitor Kunitz type 1 (SPINT1) gene, is a membrane-associated proteinase inhibitor that potently inhibits a variety of serine proteinases, including those that are membrane bound. Although HAI-1/SPINT1 is widely expressed by epithelial cells and cancer cells, its functional role is still unclear, particularly in cancer. Here, we show that stable knockdown of HAI-1/SPINT1 in the human pancreatic cancer cell… CONTINUE READING
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