Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo.

  title={Hepatocyte growth factor activator (HGFA): pathophysiological functions in vivo.},
  author={Hiroaki Kataoka and Makiko Kawaguchi},
  journal={The FEBS journal},
  volume={277 10},
Hepatocyte growth factor activator (HGFA) is a serine protease initially identified as a potent activator of hepatocyte growth factor/scatter factor. Hepatocyte growth factor/scatter factor is known to be critically involved in tissue morphogenesis, regeneration, and tumor progression, via its receptor, MET. In vivo, HGFA also activates macrophage-stimulating protein, which has roles in macrophage recruitment and inflammatory processes, cellular survival and wound healing through its receptor… CONTINUE READING

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