Hepatocyte growth factor

@article{Michalopoulos1992HepatocyteGF,
  title={Hepatocyte growth factor},
  author={George K. Michalopoulos and Reza Zarnegar},
  journal={Hepatology},
  year={1992},
  volume={15}
}
The two papers in this issue of HEPATOLOGY (1, 2) dealing with hepatocyte growth factor (HGF) underscore the increasing importance of this novel growth factor in relation to hepatic growth biology. The emerging literature has already established HGF as a growth factor with potential importance not only for the liver but for other tissues such as the kidney, placenta, brain, lung, pancreas and hemopoietic tissues. This editorial will attempt to correlate the findings of the two HGF papers… Expand
HGF and liver regeneration
TLDR
There are three main polypeptide growth factors which control hepatocyte proliferation, and when given by themselves, in serum free chemically defined cell culture media, in sufficient concentrations these growth factors will recruit quiescent hepatocytes into DNA synthesis. Expand
Hepatocyte growth factor (HGF) and its receptor (Met) in liver regeneration, neoplasia, and disease
TLDR
Because plasma HGF level significantly increases in the peripheral blood, HGF is found to be compatible with the early findings documenting the rapid emergence of blood borne hepatotrophic factors following a partial hepatectomy. Expand
Hepatocyte growth factor and the kidney: it is not just for the liver.
TLDR
Data showing the in vitro actions of HGF on renal epithelial cells that result in such diverse responses as mitogenesis, motogenesis, and morphogenesis are reviewed and in vivo evidence linking HGF and the c-met receptor to kidney development, regeneration following injury, and renal disease is examined. Expand
Hepatocyte growth factor enhances B-cell activity.
TLDR
Results are presented here demonstrating that in addition to hepatotrophic effects, HGF also possesses immunologic activity, and addition of HGF to B6C3F1 mouse spleen cell cultures enhanced humoral immune responses by augmenting the ability of B-cells to secrete immunoglobulin. Expand
Hepatocyte growth factor: A regulator of inflammation and autoimmunity.
TLDR
The actions and mechanisms of HGF in inflammation and immunity and the therapeutic potential of this factor for the treatment of inflammatory and autoimmune diseases are discussed. Expand
Hepatic regeneration and growth factors
TLDR
The model of partial hepatectomy in rats has provided numerous findings on the existence of this regulatory process, and the principal characteristics of some of these augmentors, as recently identified by the group, are reported here. Expand
Hepatocyle Growth (scatter) factor
TLDR
Study in experimental models suggest that administration of HGF may provide therapeutic benefit for conditions including pulmonary fibrosis, emphysema, asthma, and pulmonary hypertension, however, excessive HGF activity or c-met expression is associated with tumor growth and metastasis and c- Met mutations have been detected in a variety of human cancers. Expand
The role of hepatocyte growth factor/scatter factor in hepatoblastoma and hepatocellular carcinoma progression
TLDR
It is demonstrated that HGF/SF mediates cytoprotective functions against the apoptotic inducers cisplatin, camptothecin, and starvation in a phosphoinositide 3-kinase (PI3K)dependent manner, thereby contributing to chemotherapy resistance and should be considered as a candidate for therapeutic strategies. Expand
Growth Factors in the Fetal-Placental Unit
The term growth factor is generally used to describe small polypeptides that act locally to modulate cell growth and differentiation. Broadening of the use of this term is dictated by recent advancesExpand
Molecular Pathways in Hepatocyte Proliferation
In the liver, most of the hepatocyte population resides in the G0 compartment of the cell cycle and exit into the G1 phase is achieved after an insult or injury stimulus is given (Michalopoulos,Expand
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References

SHOWING 1-10 OF 59 REFERENCES
Possible endocrine control by hepatocyte growth factor of liver regeneration after partial hepatectomy.
TLDR
While HGF production was induced in the remnant liver during regeneration after partial hepatectomy, the initial trigger may not be the liver-derived HGF, rather, it may be HGF derived from extrahepatic organs, via blood circulation. Expand
Sequestration of a hepatocyte growth factor in extracellular matrix in normal adult rat liver.
TLDR
The results indicate that HGF is sequestered in the extracellular matrix in the subendothelial space in normal adult rat liver and its effect will be either neutralized or potentiated by other local factors. Expand
Characterization of the effects of human placental HGF on rat hepatocytes
TLDR
Human placenta HGF was isolated in high purity as a single chain molecule and characterized its biologic effect on rat hepatocytes, which responded to HGF in a dose‐dependent manner as the hepatocytes from normal liver. Expand
Hepatocyte growth factor in human placenta and trophoblastic disease.
TLDR
The purification of HGF from human placenta with heparin-agarose chromatography and TSK-heparin high-pressure liquid chromatography is demonstrated and the distribution of placental HGF is described by immunohistochemistry using a polyclonal antibody to HGF. Expand
Evidence for the identity of human scatter factor and human hepatocyte growth factor.
TLDR
Structural and functional evidence is presented that human SF and human HGF are identical proteins encoded by a single gene and SF in fact acts as a hepatocyte growth factor, which stimulates DNA synthesis of activity and induces invasiveness of various epithelial cells. Expand
Liver regeneration: molecular mechanisms of growth control.
  • G. Michalopoulos
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1990
TLDR
The amino acid sequence of HPTA/HGF recently became clear and revealed interesting structural homologies in a molecule that might become the largest known growth factor, presenting the positive and negative evidence that constitutes the TGF beta paradox of liver regeneration. Expand
A Portal Blood Factor as the Humoral Agent in Liver Regeneration
TLDR
It was demonstrated, by use of extracorporeal cross-circulation, that a humoral factor responsible for liver regeneration does not arise from the liver remnant and that the onset of regeneration is the result of a quantitative imbalance between the available portal blood factor and the number of liver cells present. Expand
Hepatocyte growth factor in ascites from patients with cirrhosis.
TLDR
Findings suggest that HGF is secreted into the ascites from the plasma or liver of patients with cirrhosis and may increase in the plasma with the development of hepatic impairment and act in repair of the damaged liver of Patients with chronic liver disease. Expand
Control of hepatocyte replication by two serum factors.
Serum proteins from hepatectomized or control rats were separated by gel permeation chromatography and assayed for stimulation of hepatocyte proliferation in primary cultures of hepatocytes. TwoExpand
Molecular cloning and expression of human hepatocyte growth factor
TLDR
The nucleotide sequence of the human HGF cDNA reveals that both α- andβ-chains are contained in a single open reading frame coding for a pre-pro precursor protein of 728 amino acids, which indicates that the activity of HGF is not species-specific. Expand
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