Hepatocyte growth factor (HGF) protects c-met-expressing Burkitt's lymphoma cell lines from apoptotic death induced by DNA damaging agents.

@article{Skibinski2001HepatocyteGF,
  title={Hepatocyte growth factor (HGF) protects c-met-expressing Burkitt's lymphoma cell lines from apoptotic death induced by DNA damaging agents.},
  author={Grzegorz Skibinski and Anna Skibinska and Keith James},
  journal={European journal of cancer},
  year={2001},
  volume={37 12},
  pages={1562-9}
}
The relative sensitivity of neoplastic cells to DNA damaging agents is a key factor in cancer therapy. In this paper, we show that pretreatment of Burkitt's lymphoma cell lines expressing the c-met protooncogene with hepatocyte growth factor (HGF) protects them from death induced by DNA damaging agents commonly used in tumour therapy. This protection was… CONTINUE READING