Hepatocyte growth factor/scatter factor expression and c-met in primary breast cancer.

@article{Nagy1996HepatocyteGF,
  title={Hepatocyte growth factor/scatter factor expression and c-met in primary breast cancer.},
  author={Judit Kolozsv{\'a}ri Nagy and G W Curry and Kenneth J. Hillan and Ian C McKay and Elizabeth Mallon and Anand David Purushotham and W. David George},
  journal={Surgical oncology},
  year={1996},
  volume={5 1},
  pages={15-21}
}
Hepatocyte growth factor/scatter factor (HGF/SF) is a fibroblast-derived cytokine whose receptor is encoded by c-met. Activation of c-met promotes tumour cell proliferation, dissociation, invasiveness and angiogenesis. Aberrant expression of HGF/SF or c-met may play a role in tumour progression. HGF/SF and c-met were determined in 73 breast cancers (median follow up: 61 months) and 10 samples of tumour-free breast tissue. HGF/SF was detected at significantly higher concentrations in breast… CONTINUE READING
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