Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+).

@article{Weimar1998HepatocyteGF,
  title={Hepatocyte growth factor/scatter factor (HGF/SF) is produced by human bone marrow stromal cells and promotes proliferation, adhesion and survival of human hematopoietic progenitor cells (CD34+).},
  author={I S Weimar and Nelcy Miranda and Emilie J Muller and Annemarie Hekman and Jan Martijn Kerst and Gijsbert C de Gast and Winald R. Gerritsen},
  journal={Experimental hematology},
  year={1998},
  volume={26 9},
  pages={885-94}
}
The fate of hematopoietic progenitor cells (HPCs) in the bone marrow (BM) microenvironment is determined by two different interactions: 1) they adhere (via integrins) to both extracellular matrix molecules and BM stromal cells; and 2) stromal cells produce cytokines that influence their survival, proliferation, differentiation, and mobilization. The ligands… CONTINUE READING