Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair

@article{Madonna2010HepatocyteGF,
  title={Hepatocyte growth factor/Met gene transfer in cardiac stem cells—potential for cardiac repair},
  author={Rosalinda Madonna and Gregg D. Rokosh and Raffaele de Caterina and Roberto Bolli},
  journal={Basic Research in Cardiology},
  year={2010},
  volume={105},
  pages={443-452}
}
The adult heart has been recently recognized as a self-renewing organ that contains a pool of committed resident cardiac stem cells (CSCs) and cardiac progenitor cells (CPCs). These adult CSCs and CPCs can be induced by cytokines and growth factors to migrate, differentiate, and proliferate in situ and potentially replace lost cardiomyocytes. Ligand-receptor systems, such as the tyrosine kinase receptor mesenchymal–epithelial transition factor (Met) and its ligand hepatocyte growth factor (HGF… CONTINUE READING

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