Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.

Abstract

Hepatocytes are well coupled by gap junctions, which allow the diffusion of small molecules between cells. Although gap junctions in many tissues are permeable to molecules larger than cAMP and in several preparations gap junctions pass cAMP itself, little direct evidence supports permeation by other second-messenger species. Ca2+, perhaps the smallest… (More)

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@article{Sez1989HepatocyteGJ, title={Hepatocyte gap junctions are permeable to the second messenger, inositol 1,4,5-trisphosphate, and to calcium ions.}, author={Juan C S{\'a}ez and Jennie Connor and D. C. Spray and Michael Bennett}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1989}, volume={86 8}, pages={2708-12} }