Hepatocyte encapsulation for enhanced cellular functions.

@article{Chia2000HepatocyteEF,
  title={Hepatocyte encapsulation for enhanced cellular functions.},
  author={S M Chia and Kam W. Leong and J. Li and X Xu and Ke Zeng and Podgaets Er and S J Gao and H Yu},
  journal={Tissue engineering},
  year={2000},
  volume={6 5},
  pages={
          481-95
        }
}
  • S. Chia, K. Leong, H. Yu
  • Published 1 October 2000
  • Medicine, Biology, Engineering
  • Tissue engineering
An efficient bioartificial liver-assisted device can sustain the lives of patients with acute liver failure. Among different configurations of the bioreactor design, hepatocyte encapsulation has important features that satisfy most requirements of the device. We have encapsulated rat hepatocytes in a two-layer polymeric membrane by complex coacervation using a simple setup and demonstrated enhanced cellular functions up to three times higher than those of the monolayer control. These… 
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