Hepatocyte encapsulation for enhanced cellular functions.

@article{Chia2000HepatocyteEF,
  title={Hepatocyte encapsulation for enhanced cellular functions.},
  author={S. Chia and K. Leong and J. Li and X. Xu and K. Zeng and P. N. Er and S. Gao and H. Yu},
  journal={Tissue engineering},
  year={2000},
  volume={6 5},
  pages={
          481-95
        }
}
An efficient bioartificial liver-assisted device can sustain the lives of patients with acute liver failure. Among different configurations of the bioreactor design, hepatocyte encapsulation has important features that satisfy most requirements of the device. We have encapsulated rat hepatocytes in a two-layer polymeric membrane by complex coacervation using a simple setup and demonstrated enhanced cellular functions up to three times higher than those of the monolayer control. These… Expand
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