Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo.

@article{Sgodda2007HepatocyteDO,
  title={Hepatocyte differentiation of mesenchymal stem cells from rat peritoneal adipose tissue in vitro and in vivo.},
  author={Malte Sgodda and Hendryk Aurich and S. Kleist and Ines Aurich and Sarah Koenig and Matthias M. Dollinger and Wolfgang E. Fleig and Bruno Christ},
  journal={Experimental cell research},
  year={2007},
  volume={313 13},
  pages={2875-86}
}
Mesenchymal tissues harbour stromal cells capable of multilineage differentiation. Here, we demonstrate the isolation of mesenchymal stem cells (MSC) from rat peritoneal adipose tissue capable of osteogenic and adipogenic differentiation. Under in vitro conditions favouring hepatocyte differentiation, these MSC gained characteristic functions of hepatocytes such as the capacity to synthesize urea or store glycogen. Hepatocyte-specific transcripts of dipeptidylpeptidase type IV (CD26), albumin… CONTINUE READING