Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function.

@article{Zinchenko2006HepatocyteAK,
  title={Hepatocyte and kupffer cells co-cultured on micropatterned surfaces to optimize hepatocyte function.},
  author={Yekaterina S Zinchenko and Laura W. Schrum and Mark G. Clemens and Robin N Coger},
  journal={Tissue engineering},
  year={2006},
  volume={12 4},
  pages={751-61}
}
One strategy for temporarily extending the lives of patients with liver failure is the use of bioartificial liver (BAL) support devices. The functional components of BALs are the parenchymal liver cells known as hepatocytes. One design option for further improving current BAL performance levels is to include the non-parenchymal cells of the liver (e.g., Kupffer cells) in the design. In the current study, the effect of Kupffer cells on hepatocyte function was investigated using micropatterned co… CONTINUE READING