Hepatocyte Toll-like Receptor 4 Regulates Obesity-Induced Inflammation and Insulin Resistance

@inproceedings{Jia2014HepatocyteTR,
  title={Hepatocyte Toll-like Receptor 4 Regulates Obesity-Induced Inflammation and Insulin Resistance},
  author={Lin Jia and Claudia R. Vianna and Masahiro Fukuda and Eric D. Berglund and Chen Liu and Caroline Tao and Kai Sun and Tiemin Liu and Matthew James Zacharias Harper and Charlotte Lee and Syann Lee and Philipp E Scherer and Joel K Elmquist},
  booktitle={Nature communications},
  year={2014}
}
Chronic low-grade inflammation is a hallmark of obesity and thought to contribute to the development of obesity-related insulin resistance. Toll-like receptor 4 (Tlr4) is a key mediator of pro-inflammatory responses. Mice lacking Tlr4s are protected from diet-induced insulin resistance and inflammation; however, which Tlr4-expressing cells mediate this effect is unknown. Here we show that mice deficient in hepatocyte Tlr4 (Tlr4LKO) exhibit improved glucose tolerance, enhanced insulin… CONTINUE READING
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