Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk

@inproceedings{Mtrai2011HepatocyteTargetedEB,
  title={Hepatocyte-Targeted Expression by Integrase-Defective Lentiviral Vectors Induces Antigen-Specific Tolerance in Mice with Low Genotoxic Risk},
  author={Janka M{\'a}trai and Alessio Cantore and Cynthia C. Bartholomae and Andrea Daniele Annoni and Wei Wang and Abel Acosta-Sanchez and Ermira Samara-Kuko and Liesbeth M H De Waele and Ling Ma and Pietro Genovese and Martina Damo and Anne Arens and Kevin S Goudy and Timothy C Nichols and Christof von Kalle and Marinee K. L. Chuah and Maria Grazia Roncarolo and Manfred Schmidt and Thiery C Vandendriessche and Luigi Naldini},
  booktitle={Hepatology},
  year={2011}
}
UNLABELLED Lentiviral vectors are attractive tools for liver-directed gene therapy because of their capacity for stable gene expression and the lack of preexisting immunity in most human subjects. However, the use of integrating vectors may raise some concerns about the potential risk of insertional mutagenesis. Here we investigated liver gene transfer by integrase-defective lentiviral vectors (IDLVs) containing an inactivating mutation in the integrase (D64V). Hepatocyte-targeted expression… CONTINUE READING
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