Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair

@inproceedings{Fukushima2018HepatocyteGF,
  title={Hepatocyte Growth Factor Activator: A Proteinase Linking Tissue Injury with Repair},
  author={Tsuyoshi Fukushima and Shuichiro Uchiyama and Hiroyuki Tanaka and Hiroaki Kataoka},
  booktitle={International journal of molecular sciences},
  year={2018}
}
Hepatocyte growth factor (HGF) promotes pleiotropic signaling through its specific receptor tyrosine kinase, MET. As such, it has important roles in the regeneration of injured tissues. Since HGF is produced mainly by mesenchymal cells and MET is expressed in most epithelial, endothelial and somatic stem cells, HGF functions as a typical paracrine growth factor. HGF is secreted as an inactive precursor (proHGF) and requires proteolytic activation to initiate HGF-induced MET signaling. HGF… CONTINUE READING
1
Twitter Mention

Citations

Publications citing this paper.
SHOWING 1-2 OF 2 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 63 REFERENCES

Hepatocyte growth factor activator (HGFA): Its regulation by protein C inhibitor

K. Suzuki
  • FEBS J
  • 2010
VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Activation of the zymogen of hepatocyte growth factor activator by thrombin.

  • The Journal of biological chemistry
  • 1993
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL