Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment

@inproceedings{Rothenberger2017HepatocyteGF,
  title={Hepatocyte Growth Factor/c-Met Signaling in Head and Neck Cancer and Implications for Treatment},
  author={Natalie J. Rothenberger and Laura P. Stabile},
  booktitle={Cancers},
  year={2017}
}
Aberrant signaling of the hepatocyte growth factor (HGF)/c-Met pathway has been identified as a promoter of tumorigenesis in several tumor types including head and neck squamous cell carcinoma (HNSCC). Despite a relatively low c-Met mutation frequency, overexpression of HGF and its receptor c-Met has been observed in more than 80% of HNSCC tumors, with preclinical and clinical studies linking overexpression with cellular proliferation, invasion, migration, and poor prognosis. c-Met is activated… CONTINUE READING
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