Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid.

@article{Takizawa2003HepatocellularTI,
  title={Hepatocellular tumor induction in heterozygous p53-deficient CBA mice by a 26-week dietary administration of kojic acid.},
  author={Tamotsu Takizawa and Kunitoshi Mitsumori and Toru Tamura and M. Nasu and Makoto Ueda and Toshio Imai and Masao Hirose},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  year={2003},
  volume={73 2},
  pages={287-93}
}
In order to evaluate the tumorigenic potential of kojic acid (KA), used as a food additive for preventing enzymatic browning of crustaceans and a cosmetic agent for the purpose of skin whitening, heterozygous p53-deficient CBA [p53(+/-)] mice, which are recognized as useful for detecting genotoxic carcinogens, and wild-type littermates [p53(+/+) mice] were fed diet containing 0, 1.5, and 3% KA for 26 weeks. KA induced diffuse hypertrophy and hyperplasia of thyroid follicular epithelial cells… CONTINUE READING

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