Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma.

@article{Plentz2004HepatocellularTS,
  title={Hepatocellular telomere shortening correlates with chromosomal instability and the development of human hepatoma.},
  author={Ruben R. Plentz and Martin Caselitz and Joerg S. Bleck and Michael Gebel and Peer Flemming and Stefan Kubicka and Michael P Manns and K Lenhard Rudolph},
  journal={Hepatology},
  year={2004},
  volume={40 1},
  pages={
          80-6
        }
}
  • Ruben R. Plentz, Martin Caselitz, +5 authors K Lenhard Rudolph
  • Published in Hepatology 2004
  • Biology, Medicine
  • The telomere hypothesis of cancer initiation indicates that telomere shortening initiates cancer by induction of chromosomal instability. To test whether this hypothesis applies to human hepatocellular carcinoma (HCC), we analyzed the telomere length of hepatocytes in cytological smears of fine-needle biopsies of liver tumors from patients with cirrhosis (n = 39). The tumors consisted of 24 HCC and 15 regenerative nodules as diagnosed by combined histological and cytological diagnostics. In… CONTINUE READING

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