Hepatocellular damage in porcine endotoxemia: beneficial effects of selective versus non-selective nitric oxide synthase inhibition?

@article{Saetre2001HepatocellularDI,
  title={Hepatocellular damage in porcine endotoxemia: beneficial effects of selective versus non-selective nitric oxide synthase inhibition?},
  author={Torunn Saetre and Torstein Hovig and Magnus T R\oger and Yngvar Gundersen and Ansgar Oddne Aasen},
  journal={Scandinavian journal of clinical and laboratory investigation},
  year={2001},
  volume={61 7},
  pages={503-12}
}
UNLABELLED While nitric oxide (NO) is implicated as an important mediator of hypotension in sepsis and endotoxemia, its role as a mediator of tissue injury in shock is controversial. During porcine endotoxemia (lipopolysaccharide (LPS) 1.7 microg kg(-1) x h(-1) i.v. for 6 h), we compared circulatory and morphological changes in the liver induced by two different NO synthase inhibitors (N(G)-nitro-L-arginine methyl ester, L-NAME, 25 mg x kg(-1) i.v. and aminoethyl-isothiourea, AE-ITU, 10 mg x kg… CONTINUE READING

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