Hepatocellular damage from non-steroidal anti-inflammatory drugs.

  title={Hepatocellular damage from non-steroidal anti-inflammatory drugs.},
  author={Niall O'connor and P I Dargan and Alison Linda Jones},
  journal={QJM : monthly journal of the Association of Physicians},
  volume={96 11},
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for the management of rheumatological disorders, and as analgesics and antipyretics. Hepatotoxicity is an uncommon, but potentially lethal complication, which usually occurs within 12 weeks of starting therapy. It can occur with all NSAIDs, but appears to be more common with diclofenac and particularly sulindac. Female patients aged >50 years, with autoimmune disease, and those on other potentially hepatotoxic drugs, appear to be… CONTINUE READING


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