Hepatocellular carcinoma-related cyclin D1 is selectively regulated by autophagy degradation system.

Abstract

Dysfunction of degradation machineries causes cancers, including hepatocellular carcinoma (HCC). Overexpression of cyclin D1 in HCC has been reported. We previously reported that autophagy preferentially recruits and degrades the oncogenic microRNA (miR)-224 to prevent HCC. Therefore, in the present study, we attempted to clarify whether cyclin D1 is… (More)
DOI: 10.1002/hep.29781

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