Hepatocellular carcinoma presenting as spinal cord compression in Native Americans with controlled hepatitis C: two case reports

  title={Hepatocellular carcinoma presenting as spinal cord compression in Native Americans with controlled hepatitis C: two case reports},
  author={Maksim Liaukovich and Susan Y. Wu and Sydney Yoon and Jeffrey A. Schaffer and Jen-Chin Wang},
  journal={Journal of Medical Case Reports},
BackgroundHepatocellular carcinoma is a common malignancy in Asia. It is associated with chronic hepatitis B virus or hepatitis C virus infection and alcoholic hepatitis. Commonly, the tumor metastasizes to the lungs, regional lymph nodes, and bone. Recently, the incidence of metastatic spinal cord compression caused by primary hepatocellular carcinoma has been reported more frequently due to improved diagnosis and therapeutic modalities. The presentation of primary hepatocellular carcinoma… Expand
1 Citations
Spinal Cord Compression as Initial Presentation in Hepatocellular Carcinoma
Two cases of HCC where spinal cord compression was the initial presentation before the diagnosis of H CC are presented, and a young man who presented with cord compression symptoms, which included bilateral leg weakness and an inability to void is presented. Expand


Metastatic Hepatocellular Carcinoma With Associated Spinal Cord Compression
A review of the literature demonstrated that most cases from hepatocellular carcinoma metastasizing to the spinal cord involve either the thoracic or lumbar levels and arise from the right liver lobe or both lobes. Expand
Spinal cord compression: an unusual presentation of hepatocellular carcinoma
A patient who presented with paraplegia as a first presentation of hepatocellular carcinoma with progressive leg weakness that was associated with a dull back ache and inability to pass urine and stool is described. Expand
Asymptomatic Advanced Hepatocellular Carcinoma Presenting with Spinal Cord Compression
A patient with asymptomatic advanced HCC, normal LFTs, and normal AFP values presenting with spinal cord compression is reported here. Expand
Cervical Spinal Cord Compression: A Rare Presentation of Hepatocellular Carcinoma
A case of 58-year-old male with liver cirrhosis presenting as neck pain revealed metastatic HCC to cervical spinal cord resulting in acute cord compression and patient has been treated with neurosurgical intervention. Expand
Cervical mass as the presenting manifestation of hepatocellular carcinoma.
This unusual clinical manifestation along with the above-described rare presentations of hepatocellular carcinoma must be taken into account, especially among patients with chronic hepatitis infections. Expand
Hepatocellular Carcinoma with Cervical Spine and Pelvic Bone Metastases Presenting as Unknown Primary Neoplasm.
HCC should be considered as a differential diagnosis when evaluating the primary origin of metastatic carcinoma, in a patient who presented with a metastatic bone lesion but no primary intrahepatic tumor. Expand
Hepatocellular Carcinoma with Acute Spinal Cord Compression as the Initial Presentation
The authors describe a 60-year-old man presented with a sudden onset of bilateral lower limb weakness and a sensory level at T8, and a diagnosis of HCC with epidural metastasis was made after surgical removal of the tumor mass. Expand
Spinal cord compression secondary to bone metastases from hepatocellular carcinoma.
The awareness that SCC could be a potential complication of bone metastases due to HCC is of significance in initiation of early treatment that can improve the quality of life and survival of the patients, if diagnosed earlier. Expand
MRI and CT of metastatic hepatocellular carcinoma causing spinal cord compression.
Two of the five patients in this series presented initially with skeletal metastases which led to the diagnosis of hepatocellular carcinoma, and the radiographic, magnetic resonance imaging (MRI) and computed tomography (CT) features are highlighted. Expand
Hepatocellular carcinoma in the Asia pacific region
The importance of HCC may decrease in two to three decades when the prevalence of chronic HBV infection decreases as a result of the universal HBV vaccination programs implemented in late 1980s in most Asia‐Pacific countries, and because of reduced incidence of medical transmission of HCV. Expand