Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections.

@article{Korba1989HepatocellularCI,
  title={Hepatocellular carcinoma in woodchuck hepatitis virus-infected woodchucks: presence of viral DNA in tumor tissue from chronic carriers and animals serologically recovered from acute infections.},
  author={Brent E. Korba and F V Wells and Betty H Baldwin and Paul J. Cote and Bud Christopher Tennant and Hans Popper and John L. Gerin},
  journal={Hepatology},
  year={1989},
  volume={9 3},
  pages={461-70}
}
During long-term studies of the natural history of woodchuck hepatitis virus infection, five cases of histologically confirmed, primary hepatocellular carcinoma were observed in a total of 92 woodchucks which had recovered, by analysis of viral serologic markers (WHsAg-, anti-WHc+, anti-WHs+), from experimental acute woodchuck hepatitis virus infections 20 to 30 months prior to the detection of hepatocellular carcinoma. No hepatocellular carcinoma was observed in 167 uninfected controls at… CONTINUE READING
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