Hepatocellular carcinoma cell cycle: study of Long-Evans cinnamon rats.

@article{Masaki2000HepatocellularCC,
  title={Hepatocellular carcinoma cell cycle: study of Long-Evans cinnamon rats.},
  author={Tsutomu Masaki and Yasushi Shiratori and William Otero Rengifo and Kazumasa Igarashi and Katsura Matsumoto and Masayuki Nishioka and Yasue Hatanaka and Masao Omata},
  journal={Hepatology},
  year={2000},
  volume={32 4 Pt 1},
  pages={
          711-20
        }
}
Amplification found in a number of cyclin genes, especially in cyclin D and E, is an important event process that takes place in cancers, including hepatocellular carcinoma (HCC). The activities of a wide range of cell cycle-related kinases remain obscure in HCC. The purpose of the present study is to determine the cyclins and kinase activities of HCC in Long-Evans Cinnamon (LEC) rats. Cyclin D1, E, A, H, Cdk1(cyclin-dependent kinase; Cdc2), Cdk4, and Cdk6 protein levels were determined by… CONTINUE READING
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