Hepatocellular carcinoma associated with recreational anabolic steroid use

@article{Gorayski2007HepatocellularCA,
  title={Hepatocellular carcinoma associated with recreational anabolic steroid use},
  author={Peter Gorayski and Campbell H. Thompson and H. S. Subhash and A Thomas},
  journal={British Journal of Sports Medicine},
  year={2007},
  volume={42},
  pages={74 - 75}
}
A 35-year-old male bodybuilder was found to have a hepatocellular carcinoma (HCC) arising in a pre-existing hepatic adenoma following recreational anabolic steroid use. Given the widespread use of recreational anabolic steroids, another potentially life-threatening complication is highlighted in addition to the more commonly recognised hepatic adenoma. Malignant transformation to HCC from a pre-existing hepatic adenoma confirmed by immunohistochemical study has previously not been reported in… 
Development of Hepatocellular Carcinoma Associated with Anabolic Androgenic Steroid Abuse in a Young Bodybuilder: A Case Report
TLDR
The presented case may indicate aetiological association of chronic intake of AAS and the development of HCC in a 37-year-old male professional bodybuilder with extensive anabolic androgenic (AAS) steroid abuse.
Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage.
TLDR
This is the first reported case of hepatic adenoma re-growth with recidivistic steroid abuse, complicated by life-threatening hemorrhage, and athletes and bodybuilders should continue to be counseled about its serious medical risks.
Hepatocellular carcinoma in body builders; an emerging rare but serious complication of androgenic anabolic steroid use
TLDR
A rare and not widely known about, but potentially fatal adverse effect of AAS, now becoming prevalent with the high use of these drugs is reported, which is important for doctors to be aware of.
Recreational Anabolic-Androgenic Steroid Use Associated With Liver Injuries Among Brazilian Young Men
TLDR
The results suggest that the risk of AAS use for the liver may be greater than the esthetic benefits, and demonstrate the importance of screening AAS users for liver injuries.
[Multiple hepatocellular adenomas and renal cell carcinoma associated with anabolic androgenic steroids].
TLDR
In the authors' opinion, liver adenomatosis and renal cancer have the same cause in this case (chronic toxic effect of androgens).
Testosterone-receptor positive hepatocellular carcinoma in a 29-year old bodybuilder with a history of anabolic androgenic steroid abuse: a case report
TLDR
Hepatocellular carcinoma occurring in association with anabolic androgenic steroid abuse should sensitize physicians and especially professional bodybuilders for the harmful use of high doses of steroids.
Histological Effect of Androgenic Anabolic Steroids on Liver
TLDR
The damage of the liver cells or at least increased permeability of the hepatocellular membranewhich is noticed in the present work could explain the increment of plasma levels of liver enzymes which was studied by other researchers, as they notice an elevation liver enzymes activity.
Exploring the link between anabolic-androgenic steroids abuse for performance improvement and hepatocellular carcinoma: a literature review
TLDR
The evidence that HCC has been linked to long term AAS abuse for performance improvement is scant but some association is suggested and public policies are made to make high risk populations aware of the risks of misuse and self-administration.
Relevance of low testosterone to nonalcoholic fatty liver disease
TLDR
The aims of this review are to discussed the available experimental and epidemiological data evaluating the association between testosterone and NAFLD, to discuss the potential clinical relevance of these data, and to identify gaps in the literature.
Anabolic Steroid Abuse and Dependence in Clinical Practice
  • K. Brower
  • Medicine, Psychology
    The Physician and sportsmedicine
  • 2009
TLDR
All physicians who treat nonmedical AAS users will benefit from an understanding of these psychological variables, including the potential for AAS to cause dependence, and guidelines are suggested for assessment and treatment.
...
...

References

SHOWING 1-6 OF 6 REFERENCES
Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: a report of two cases and a review of the literature
TLDR
Sportsmen taking AAS should be considered as a group at risk of developing hepatic sex hormone related tumours and should be carefully and periodically monitored with US studies.
Androgens and hepatocellular carcinoma in an athlete.
TLDR
An association between primary hepatic tumors and androgen therapy was first noted in 1965 and in a recent review of the literature, 33 cases of patients with androgen-assistance problems were reviewed.
Androgens and liver tumors: Fanconi's anemia and non‐Fanconi's conditions
TLDR
All patients on anabolic androgenic steroids are at risk of liver tumors, regardless of underlying diagnosis, and the magnitude of the risk cannot be determined from currently available data, because the number of patients receiving androgens is unknown.
Tumor encapsulation in hepatocellular carcinoma. A pathologic study of 189 cases
TLDR
There was no correlation between capsular thickness and liver invasion, microsatellites, venous permeation, or survivals, suggesting that formation of the tumor capsule was independent of the degree of fibrosis within and outside the tumor, and the thickness of tumor capsules was not helpful in prognostication.
Androgens and liver tumors: Fanconi’s and non-Fanconi’s conditions
  • Am J Hematol
  • 2004