Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry.

  title={Hepatocellular adenoma subtype classification using molecular markers and immunohistochemistry.},
  author={Paulette Bioulac-Sage and Sandra Rebouissou and Cristel G Thomas and J. -F. Blanc and Jean Saric and Ant{\'o}nio S{\'a} Cunha and Anne Rullier and Ga{\"e}lle Cubel and Gabrielle Couchy and Sandrine Imbeaud and Charles Balabaud and Jessica Zucman-Rossi},
  volume={46 3},
UNLABELLED Hepatocellular adenomas (HCA) with activated beta-catenin present a high risk of malignant transformation. To permit robust routine diagnosis to allow for HCA subtype classification, we searched new useful markers. We analyzed the expression of candidate genes by quantitative reverse transcription polymerase chain reaction QRT-PCR followed by immunohistochemistry to validate their specificity and sensitivity according to hepatocyte nuclear factor 1 alpha (HNF1alpha) and beta-catenin… CONTINUE READING
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