Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience

@article{BioulacSage2009HepatocellularAM,
  title={Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience},
  author={P. Bioulac-Sage and H. Laumonier and G. Couchy and B. le Bail and A. S{\'a} Cunha and A. Rullier and C. Laurent and J. Blanc and Gaelle Cubel and H. Trillaud and J. Zucman-Rossi and C. Balabaud and J. Saric},
  journal={Hepatology},
  year={2009},
  volume={50}
}
We took advantage of the reported genotype/phenotype classification to analyze our surgical series of hepatocellular adenoma (HCA). The series without specific known etiologies included 128 cases (116 women). The number of nodules varies from single, <5, and ≥5 in 78, 38, and 12 cases, respectively. The resection was complete in 95 cases. We identified 46 HNF1α‐inactivated HCAs (44 women), 63 inflammatory HCAs (IHCA, 53 women) of which nine were also β‐catenin–activated, and seven β‐catenin… Expand
Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases
TLDR
Although the new classification of Hepatocellular adenoma is now generally accepted, validation through follow-up studies is necessary. Expand
Molecular classification of hepatocellular adenoma: A single-center experience
TLDR
The mean tumor size and activation of catenin β1 mutation status might be the risk factors for the malignant transformation of HCA into HCC. Expand
Histological and Immunohistochemical Revision of Hepatocellular Adenomas: A Learning Experience
Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1α-inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β-catenin-activated HCA (b-HCA). WeExpand
Will the pathomolecular classification of hepatocellular adenomas improve their clinical management?
TLDR
A phenotypic classification of those benign tumors using immunohistochemistry has been derived from the contribution of molecular biology allowing for the differential diagnosis between FNH and HCA and the identification of HCA subtypes. Expand
Hepatocellular adenoma management: advances but still a long way to go.
TLDR
Known and new data, well accepted and that which is still controversial are presented that are related in one way or another to molecular advances in the field of HCA in the last 12 years. Expand
Benign hepatocellular nodules: what have we learned using the patho-molecular classification.
TLDR
Recent advances have broadened the clinical scope of HCA in various conditions, such as their presence in males, in obese patients, in patients suffering from liver vascular disorders, genetic diseases, however, specific immunohistochemistry has shown limitations particularly for the identification of b-HCA, thereby, outlining the importance of molecular studies to improve the diagnosis/prognosis. Expand
Hepatocellular adenomas: review of pathological and molecular features.
TLDR
The management of HCA is now based on multidisciplinary approach including clinicians, radiologists and pathologists integrating gender, tumor size, and HCA subtyping. Expand
Pathology of Hepatocellular Adenoma: Subtypes and Rare Morphologic Features
TLDR
Besides the classic morphologic features; granuloma formation, pigmentation, bone marrow metaplasia can be seen in HAs; although the prognostic significance of those is not known, they are considered to have a role in the development and progression of HA. Expand
Pathological diagnosis of hepatocellular adenoma in clinical practice
TLDR
Immunohistochemical analysis is particularly helpful to identify b-HCA prone to develop hepatocellular carcinoma (HCC) and also to differentiate between focal nodular hyperplasia, HCA and HCC. Expand
Unique genetic alterations and clinicopathological features of hepatocellular adenoma in Chinese population.
TLDR
The results first indicate that patients with HCA in China frequently occur in male overweigh and obese adult population, lack an association with OCs use and exhibit unique genetic alterations, suggesting that alternative pathogenetic pathways involve in HCA tumorigenesis in Chinese patients. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 28 REFERENCES
Genotype–phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC
TLDR
The molecular and pathological classification of hepatocellular adenoma permits the identification of strong genotype–phenotype correlations and suggests that adenomas with β‐catenin activation have a higher risk of malignant transformation. Expand
Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors.
TLDR
Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci. Expand
Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma.
TLDR
The recent identification of different molecular pathways that contribute to tumor development has significantly increased the knowledge of benign hepatocellular tumorigenesis and may modify the clinical practice, particularly in the diagnosis and follow-up of HCA patients. Expand
Clinical, morphologic, and molecular features defining so-called telangiectatic focal nodular hyperplasias of the liver.
TLDR
TFNHs are monoclonal lesions frequently subject to bleeding that are similar to adenomas not carrying HNF1alpha mutations and require a similar type of treatment and support the hypothesis that TFNH is a separate entity. Expand
Association of adenoma and focal nodular hyperplasia: experience of a single French academic center
TLDR
The association of FNH and adenoma could be coincidental or secondary to shared causal mechanisms: a) systemic and local angiogenic abnormalities induced by oral contraceptives; b) tumor-induced growth factors; c) thrombosis and local arterio-venous shunting. Expand
Surgical Management of Hepatocellular Adenoma: Take It or Leave It?
TLDR
Surgical resection over observation is recommended over observation if patient comorbidities and anatomic location of HA are favorable, and a laparoscopic approach can be safely used in selected cases. Expand
Hepatocellular adenomas: Magnetic resonance imaging features as a function of molecular pathological classification
TLDR
HNF‐1α–mutated HCAs and inflammatory HCAs were associated with specific MRI patterns related to diffuse fat repartition and sinusoidal dilatation, respectively. Expand
Case reportLiver adenomatosis: An entity distinct from liver adenoma?
TLDR
From 1979 to 1984, this work followed the cases of 3 men and 2 women suffering from liver adenomatosis, an uncommon lesion consisting of numerous benign adenomas in an otherwise normal hepatic parenchyma. Expand
Inflammatory syndrome with liver adenomatosis: the beneficial effects of surgical management
TLDR
A case of a patient with an inflammatory syndrome cured after resection of an adenoma, which was confirmed by magnetic resonance imaging (MRI), and three additional 1-cm-nodules in the same lobe. Expand
Multiple black hepatocellular adenomas in a male patient.
TLDR
It is concluded that this male patient with multiple adenomas and mild iron overload is at risk of developing an hepatocellular carcinoma and that the black colour ofAdenomas is probably due to a partial defect in excretion of organic anions. Expand
...
1
2
3
...