Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience

  title={Hepatocellular adenoma management and phenotypic classification: The Bordeaux experience},
  author={Paulette Bioulac-Sage and Herv{\'e} Laumonier and Gabrielle Couchy and Brigitte le Bail and Antonio Sa cunha and Anne Rullier and Christophe Laurent and Jean-Fr{\'e}d{\'e}ric Blanc and Gaelle Cubel and Herv{\'e} Trillaud and Jessica Zucman‐Rossi and Charles Balabaud and Jean Saric},
We took advantage of the reported genotype/phenotype classification to analyze our surgical series of hepatocellular adenoma (HCA). The series without specific known etiologies included 128 cases (116 women). The number of nodules varies from single, <5, and ≥5 in 78, 38, and 12 cases, respectively. The resection was complete in 95 cases. We identified 46 HNF1α‐inactivated HCAs (44 women), 63 inflammatory HCAs (IHCA, 53 women) of which nine were also β‐catenin–activated, and seven β‐catenin… 

Clinicopathological Analysis of Hepatocellular Adenoma According to New Bordeaux Classification: Report of Eight Korean Cases

Although the new classification of Hepatocellular adenoma is now generally accepted, validation through follow-up studies is necessary.

Molecular classification of hepatocellular adenoma: A single-center experience

The mean tumor size and activation of catenin β1 mutation status might be the risk factors for the malignant transformation of HCA into HCC.

Histological and Immunohistochemical Revision of Hepatocellular Adenomas: A Learning Experience

Light has been shed on the genotype/phenotype correlation in hepatocellular adenoma (HCA) recognizing HNF1α-inactivated HCA (H-HCA), inflammatory HCA (IHCA), and β-catenin-activated HCA (b-HCA). We

Will the pathomolecular classification of hepatocellular adenomas improve their clinical management?

Hepatocellular adenoma management: advances but still a long way to go.

Known and new data, well accepted and that which is still controversial are presented that are related in one way or another to molecular advances in the field of HCA in the last 12 years.

Benign hepatocellular nodules: what have we learned using the patho-molecular classification.

Pathology of Hepatocellular Adenoma: Subtypes and Rare Morphologic Features

Besides the classic morphologic features; granuloma formation, pigmentation, bone marrow metaplasia can be seen in HAs; although the prognostic significance of those is not known, they are considered to have a role in the development and progression of HA.



Genotype–phenotype correlation in hepatocellular adenoma: New classification and relationship with HCC

The molecular and pathological classification of hepatocellular adenoma permits the identification of strong genotype–phenotype correlations and suggests that adenomas with β‐catenin activation have a higher risk of malignant transformation.

Management of hepatocellular adenoma: solitary-uncomplicated, multiple and ruptured tumors.

Tumors suspected of HA, regardless of the size, should be resected, because of high chances of rupture causing bleeding, and/or containing malignant foci.

Molecular pathogenesis of focal nodular hyperplasia and hepatocellular adenoma.

Surgical Management of Hepatocellular Adenoma: Take It or Leave It?

Surgical resection over observation is recommended over observation if patient comorbidities and anatomic location of HA are favorable, and a laparoscopic approach can be safely used in selected cases.

Hepatocellular adenomas: Magnetic resonance imaging features as a function of molecular pathological classification

HNF‐1α–mutated HCAs and inflammatory HCAs were associated with specific MRI patterns related to diffuse fat repartition and sinusoidal dilatation, respectively.

Inflammatory syndrome with liver adenomatosis: the beneficial effects of surgical management

A case of a patient with an inflammatory syndrome cured after resection of an adenoma, which was confirmed by magnetic resonance imaging (MRI), and three additional 1-cm-nodules in the same lobe.

Multiple black hepatocellular adenomas in a male patient.

It is concluded that this male patient with multiple adenomas and mild iron overload is at risk of developing an hepatocellular carcinoma and that the black colour ofAdenomas is probably due to a partial defect in excretion of organic anions.

Possible association between benign hepatomas and oral contraceptives.

7 case reports of women with benign hepatic adenoma suggest that, since all of the women were taking oral contraceptives (OCs), there may be an association between ingestion of exogenous hormones

Glycogenosis storage type I diseases and evolutive adenomatosis: an indication for liver transplantation

  • J. LerutO. Ciccarelli J. Otte
  • Medicine
    Transplant international : official journal of the European Society for Organ Transplantation
  • 2003
Regular detailed Doppler ultrasound and magnetic nuclear resonance screening during childhood and adolescence are mandatory in order for the timing of transplantation to be optimized in GSD type I patients with adenomatosis, especially when tumor characteristics change.

Liver adenomatosis. An entity distinct from liver adenoma?

From 1979 to 1984, this work followed the cases of 3 men and 2 women suffering from liver adenomatosis, an uncommon lesion consisting of numerous benign adenomas in an otherwise normal hepatic parenchyma.