Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis.

@article{Margolskee2016HepatocellularAC,
  title={Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis.},
  author={Elizabeth Margolskee and Fei Bao and Anne Koehne de Gonzalez and Roger Klein Moreira and Stephen M. Lagana and Anthony N. Sireci and Antonia Rogado Sepulveda and Helen Elaine Remotti and Jay H. Lefkowitch and Marcela A Salomao},
  journal={Diagnostic pathology},
  year={2016},
  volume={11},
  pages={27}
}
BACKGROUND Four subtypes of hepatocellular adenomas (HCA) are recognized: hepatocyte-nuclear-factor-1α mutated (H-HCA), β-catenin-mutated type with upregulation of glutamine synthetase (b-HCA), inflammatory type (IHCA) with serum-amyloid-A overexpression, and unclassified type. Subtyping may be useful since b-HCA appear to have higher risk of malignant… CONTINUE READING