Hepatocellular Carcinoma in Transplantable Child-Pugh A Cirrhotics: Should Cost Affect Resection vs Transplantation?

@article{Michelakos2018HepatocellularCI,
  title={Hepatocellular Carcinoma in Transplantable Child-Pugh A Cirrhotics: Should Cost Affect Resection vs Transplantation?},
  author={T. Michelakos and Dimitrios Xourafas and Motaz Qadan and Rafael V. Pieretti-Vanmarcke and Lei Cai and Madhukar S. Patel and Joel T Adler and Fermin Fontan and Usama Basit and Parsia A. Vagefi and Nahel Elias and Kenneth K Tanabe and David H. Berger and Heidi Yeh and James F. Markmann and David C. Chang and Cristina R. Ferrone},
  journal={Journal of Gastrointestinal Surgery},
  year={2018},
  volume={23},
  pages={1135-1142}
}
BackgroundThere is no consensus regarding the optimal surgical treatment for transplantable hepatocellular carcinoma (HCC) patients with well-compensated cirrhosis. Our aim was to compare outcomes between Child-Pugh A (CPA) cirrhotics who underwent liver resection or transplantation for HCC.MethodsClinicopathologic data were retrospectively collected for all surgically treated HCC patients between 7/1992 and 12/2015. Disease-free survival (DFS) and overall survival (OS) were calculated from the… 
Poorly differentiated hepatocellular carcinoma: resection is equivalent to transplantation in patients with low liver fibrosis.
  • O. Salehi, E. Vega, C. Conrad
  • Medicine
    HPB : the official journal of the International Hepato Pancreato Biliary Association
  • 2021
The Treatment Effect of Liver Transplantation versus Liver Resection for HCC: A Review and Future Perspectives
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A comprehensive review of research articles comparing these two treatments with a focus on factors accounting for selection bias is presented and a new research design is suggested that uses a treatment guideline to help ensure that the groups are more comparable.
Liver resection versus liver transplantation for hepatocellular carcinoma within Milan criteria: a meta-analysis of 18,421 patients.
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Mortality after LR for HCC is nearly 50% higher compared to LT and the risk of recurrence after LR is threefold that of LT, and survival between LR and LT were similar in uninodular disease.
Conditional Survival in Resected Pancreatic Ductal Adenocarcinoma Patients Treated with Total Neoadjuvant Therapy
TLDR
For resected TNT-treated BR/LA PDAC patients, the probability of surviving an additional length of time increases as a function of survival already accrued and dynamic survival estimates may allow personalized follow-up and counseling.

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