Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors

@inproceedings{HernandezVargas2010HepatocellularCD,
  title={Hepatocellular Carcinoma Displays Distinct DNA Methylation Signatures with Potential as Clinical Predictors},
  author={Hector Hernandez-Vargas and M Lambert and Florence Le Calvez-Kelm and G{\'e}raldine Gouysse and Sandrine Mckay-Chopin and Sean V. Tavtigian and J. -Y. Scoazec and Zdenko Herceg},
  booktitle={PloS one},
  year={2010}
}
BACKGROUND Hepatocellular carcinoma (HCC) is characterized by late detection and fast progression, and it is believed that epigenetic disruption may be the cause of its molecular and clinicopathological heterogeneity. A better understanding of the global deregulation of methylation states and how they correlate with disease progression will aid in the design of strategies for earlier detection and better therapeutic decisions. METHODS AND FINDINGS We characterized the changes in promoter… CONTINUE READING