Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume.

@article{Roman1997HepatocellularAC,
  title={Hepatocellular ATP-binding cassette protein expression enhances ATP release and autocrine regulation of cell volume.},
  author={Richard M. Roman and Yanlin Wang and Stephen D. Lidofsky and Andrew P. Feranchak and Noureddine Lomri and Bruce F. Scharschmidt and J. Gregory Fitz},
  journal={The Journal of biological chemistry},
  year={1997},
  volume={272 35},
  pages={21970-6}
}
In a model liver cell line, recovery from swelling is mediated by a sensitive autocrine pathway involving conductive release of ATP, P2 receptor stimulation, and opening of membrane Cl- channels (Wang, Y., Roman, R. M., Lidofsky, S. D., and Fitz, J. G. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 12020-12025). However, the mechanisms coupling changes in cell volume to ATP release are not known. Based on evidence that certain ATP-binding cassette (ABC) proteins may function as ATP channels or… CONTINUE READING