Corpus ID: 21251201

Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.

@article{Yokoyama1985HepatocarcinogenicAP,
  title={Hepatocarcinogenic and promoting action of a choline-devoid diet in the rat.},
  author={S. Yokoyama and M. A. Sells and T. Reddy and B. Lombardi},
  journal={Cancer research},
  year={1985},
  volume={45 6},
  pages={
          2834-42
        }
}
Male Fisher 344 rats were solely fed a choline-supplemented diet for 65 to 105 weeks or a choline-devoid diet for 24 to 102 weeks. Hepatocellular carcinomas developed in the latter animals, beginning at 24 weeks. Other groups of rats were given a single dose of 20 mg diethylnitrosamine/kg, 18 h after a partial hepatectomy and were fed, 4 weeks thereafter, either a choline-supplemented, or a choline-devoid diet for up to 48 weeks. In rats fed the choline-supplemented diet, the only relevant… Expand
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